Robert S Molday Selected Research

Stargardt Disease

1/2022	Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration.
11/2020	Functional analysis and classification of homozygous and hypomorphic ABCA4 variants associated with Stargardt macular degeneration.
11/2019	Dual ABCA4-AAV Vector Treatment Reduces Pathogenic Retinal A2E Accumulation in a Mouse Model of Autosomal Recessive Stargardt Disease.
1/2018	Localization and functional characterization of the p.Asn965Ser (N965S) ABCA4 variant in mice reveal pathogenic mechanisms underlying Stargardt macular degeneration.
1/2018	Correlating the Expression and Functional Activity of ABCA4 Disease Variants With the Phenotype of Patients With Stargardt Disease.
1/2015	Insights into the Molecular Properties of ABCA4 and Its Role in the Visual Cycle and Stargardt Disease.
4/2014	ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal.
6/2012	ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer.
9/2011	Lipid transport by mammalian ABC proteins.
8/2011	Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4.

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Robert S Molday Research Topics

Disease

15	Stargardt Disease 01/2022 - 12/2007
11	Retinoschisis (Retinoschisis, Juvenile) 01/2016 - 04/2002
9	Macular Degeneration (Age-Related Maculopathy) 01/2018 - 12/2004
7	Retinitis Pigmentosa (Pigmentary Retinopathy) 10/2015 - 08/2003
5	Retinal Degeneration 10/2015 - 01/2011
3	Retinal Diseases 01/2020 - 06/2007
3	Intellectual Disability (Idiocy) 12/2019 - 04/2014
3	Cerebellar Ataxia (Dysmetria) 12/2019 - 04/2014
3	Disease Progression 01/2019 - 06/2008
3	Vision Disorders (Hemeralopia) 10/2015 - 09/2008
3	Leber Congenital Amaurosis 01/2014 - 12/2010
2	Nervous System Diseases (Neurological Disorders) 12/2019 - 01/2019
2	Retinal Dystrophies 02/2015 - 02/2015
2	Leber Congenital Amaurosis 12 01/2014 - 10/2013
2	Tangier Disease 11/2013 - 09/2011
2	Cone-Rod Dystrophies 07/2009 - 02/2009
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Anemia 01/2019
1	Congenital Hemolytic Anemia (Hemolytic Anemia, Congenital) 01/2019
1	Aniridia 01/2016
1	Ganglion Cysts (Ganglion) 01/2016
1	Blindness (Hysterical Blindness) 01/2016
1	congenital stationary Night blindness 10/2015
1	Dysequilibrium syndrome 04/2014
1	Inborn Genetic Diseases (Disease, Hereditary) 03/2013
1	Skin Diseases (Skin Disease) 09/2011
1	Lamellar Ichthyosis (Harlequin Ichthyosis) 09/2011
1	Ovarian Neoplasms (Ovarian Cancer) 01/2010
1	Neoplasms (Cancer) 01/2010
1	Cysts 01/2009

Drug/Important Bio-Agent (IBA)

23	Retinaldehyde (Retinal)IBA 11/2019 - 04/2002
17	Proteins (Proteins, Gene)FDA Link 11/2020 - 07/2003
9	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2018 - 12/2007
4	RetinoidsIBA 01/2022 - 01/2010
4	LipidsIBA 01/2019 - 07/2009
4	Guanylate Cyclase (Guanylyl Cyclase)IBA 01/2014 - 12/2010
3	N-retinylidene-phosphatidylethanolamineIBA 11/2020 - 06/2012
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2019 - 09/2011
2	Adenosine Triphosphate (ATP)IBA 11/2020 - 10/2010
2	AntigensIBA 01/2020 - 01/2010
2	CholesterolIBA 11/2013 - 09/2011
2	phosphatidylethanolamineIBA 06/2012 - 07/2009
2	EnzymesIBA 10/2010 - 01/2010
2	DisulfidesIBA 03/2005 - 07/2003
1	LipofuscinIBA 01/2022
1	P-type ATPasesIBA 12/2019
1	Ion Pumps (Ion Pump)IBA 12/2019
1	Phospholipid Transfer ProteinsIBA 01/2019
1	PhosphatidylserinesIBA 01/2019
1	Adenosine Triphosphatases (ATPase)IBA 01/2019
1	CalciumIBA 10/2015
1	guanylate cyclase 1IBA 02/2015
1	Isoleucine (L-Isoleucine)FDA Link 04/2014
1	Oxidoreductases (Dehydrogenase)IBA 04/2014
1	Schiff Bases (Schiff Base)IBA 04/2014
1	Vitamin A (Retinol)FDA LinkGeneric 04/2014
1	HDL LipoproteinsIBA 11/2013
1	Carrier Proteins (Binding Protein)IBA 11/2011
1	SterolsIBA 09/2011
1	Surface-Active Agents (Surfactants)IBA 09/2011
1	Pulmonary Surfactants (Pulmonary Surfactant)IBA 09/2011
1	Phosphatidylcholines (Phosphatidylcholine)IBA 09/2011
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 09/2011
1	Alanine (L-Alanine)FDA Link 08/2011
1	Retinal Pigments (Pigments, Visual)IBA 10/2010
1	Fatty Acids (Saturated Fatty Acids)IBA 10/2010
1	ImmunosorbentsIBA 01/2010
1	Biomarkers (Surrogate Marker)IBA 01/2010
1	Estrogens (Estrogen)FDA Link 01/2010
1	MucinsIBA 01/2010
1	Glycoproteins (Glycoprotein)IBA 01/2010
1	dorzolamide (Trusopt)FDA LinkGeneric 01/2009
1	Ophthalmic Solutions (Eye Drops)IBA 01/2009
1	CarbohydratesIBA 09/2008
1	Sepharose (Agarose)IBA 09/2008
1	RNA Precursors (Precursor, mRNA)IBA 05/2007
1	RNA Splicing FactorsIBA 05/2007
1	PeripherinsIBA 01/2004
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2004

Therapy/Procedure

2	Therapeutics 01/2016 - 06/2008
1	Precision Medicine 01/2020
1	Investigational Therapies (Experimental Therapy) 02/2015